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Preliminary  in vitro  cytotoxic test on different extracts of  Melicope pteleifolia  collected at Dăk Nong province, Vietnam showed that the  n -hexane one was the most potent. From this  n -hexane extract, three new quinolinone alkaloid–phenylpropanoid derivatives ( 1–3 ) and three known compounds ( 4–6 ) were isolated. Based on NMR and HR-MS analysis, their chemical structures were elucidated as melicoptines A-C ( 1–3 ), flindersine (4), 3,4,5-trimethoxybenzoic acid (5) and (24S)-methylcholestan-1α,3β-diol (6). Isolated compounds ( 1–4 ) were evaluated for their anti-bacterial and cytotoxic activities against human non-small cell lung cancer (A549), human cervical cancer (HeLa), human Burkitt’s lymphoma (Raji) and normal fibroblasts (NIH-3T3). All of them were inactive.

Three quinolinone alkaloid − phenylpropanoid adducts from Melicope pteleifolia