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One undescribed lignan, one new natural product, along with fourteen known compounds, were isolated from the roots of  Ficus hirta . The structures of the isolates were elucidated by comprehensive spectroscopic technologies, including UV, IR, HRESIMS, and NMR. The absolute configuration of  1  was determined by comparison of experimental and calculated ECD data. The cytotoxicity of all the compounds against HeLa and HepG2 cell lines was evaluated and compound  7  showed considerable cytotoxic effect towards HepG2 cells. Also, the apoptotic effect of  7  on HepG2 cells and the effect of  7  on the key proteins (p-JNK and p-p38) in MAPK (Mitogen-activated protein kinases) pathways were studied by flow cytometry and western blotting experiment. As a result, compound  7  induced the apoptosis of HepG2 cells, and dose-dependently increased the phosphorylation of JNK and p38. Thus,  7  might trigger HepG2 cells apoptosis via JNK/p38 MAPK signaling pathway.

Lignans and phenylpropanoids from the roots of Ficus hirta and their cytotoxic activities