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Twenty indole alkaloids, among which two undescribed ones named rauvolfianoids A ( 1 ) and B ( 2 ), were isolated from the stem barks of  Rauvolfia caffra  Sond along with eight other compounds from other biosynthetic pathways. The structures were elucidated by analysis of spectroscopic data, including 1 D and 2 D NMR; absolute configurations of  1  and  2  were determined by CD exciton chirality method. Compounds  1  and  2  were evaluated for antimicrobial and anticancer activities against three bacterial strains ( Escherichia coli ,  Shigella sp  and  Salmonella sp ) and CRC-related opportunistic pathogens.  1  showed moderate antibacterial activity against  Salmonella sp  with the MIC value of 25 μg/ml, while  2  exhibited weak selective activity against all tested pathogens. In addition, these alkaloids were characterized as weak apoptosis inducers in HCT116 human colon carcinoma cell line.

Antimicrobial and cytotoxic activities of indole alkaloids and other constituents from the stem barks of Rauvolfia caffra Sond (Apocynaceae)