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Using various chromatographic methods, four new phenolics, coroffesters A-D ( 1 − 4 ) were isolated from the fruit of  Cornus officinalis  (Cornaceae). Their structures ( 1 − 4 ) were elucidated unambiguously by spectroscopic methods such as one- and two-dimensional nuclear magnetic resonance (1 D- and 2 D-NMR) spectroscopy and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS). The anti-inflammatory activity of the isolated compounds was also evaluated. All compounds ( 1 − 4 ) showed moderate inhibitory activity against NO production in a dose-dependent manner in RAW 264.7 cells.

Four new phenolic compounds from the fruit of Cornus officinalis (Cornaceae) and their anti-inflammatory activity in RAW 264.7 cells