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Toona sinensis  is a medicinal and edible plant that belongs to the genus  Toona  of family Meliaceae. Phytochemical investigations carried out on this plant, seven apotirucallane-type triterpenoids ( 1–7 ), two cycloartane-type triterpenoids ( 8–9 ), four sterols ( 10–13 ), two sesquiterpenes ( 14–15 ), four phenols ( 16–19 ), and one lignin ( 20 ) were isolated from the pericarp of  T. sinensis  by silica gel column and preparative middle pressure liquid chromatography. Their structures were identified by interpretation of NMR and comparison with those reported in the literature. Compounds  11–12 ,  15–16 , and  18  were isolated from the family Meliaceae, compounds  13–14  were obtained from the genus  Toona , and compound  19  was obtained from  T. sinensis  for the first time. Additionally, the cytotoxicity and polyol pathway (PP) inhibitory activities of active constituents were evaluated in rat glomerular mesangial cells cultured under high glucose conditions, suggesting their potential application for a PP inhibitor.

Cytotoxicity and polyol pathway inhibitory activities of chemical constituents isolated from the pericarp of Toona sinensis