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Three new xanthone glycosides, canlucosides A – C ( 1 – 3 ), along with three known compounds ( 4 – 6 ), have been obtained and identified from the ethanol extract of  Canscora lucidissima . Their structures were identified according to HR-ESI-MS, 1D, 2D NMR data, ECD measurements powered by molecular calculations and optical rotation values. Compound  6  (1-hydroxy-3,7,8-trmethoxyxanthone) was isolated from  C. lucidissima  for the first time. Five compounds ( 2–6)  showed moderate antioxidant and NO inhibitory activities. Canlucosides B and C ( 2  and  3 ) showed significant antioxidant activity with IC 50  values of 33.64 ± 5.60 µM and 36.63 ± 4.32 µM, respectively. Canlucoside B ( 2 ) possessed a significant NO inhibitory effect with an IC 50  value 0.92 µM.

New xanthones from Canscora lucidissima and their antioxidant and NO inhibitory activities