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Malassezia  spp. are lipophilic fungi that are part of the normal flora of the human skin and are the etiological agents of dandruff and seborrheic dermatitis. β-Carbonic Anhydrases (CAs; EC 4.2.1.1) expressed from the pathogenic fungi are an alternative/complementary drug target. Previous work by our groups demonstrated that flavonoids and depsides can effectively inhibit  Malassezia globosa  β-CA (MgCA). In continuation of this study herein we report the inhibitory activity of a variety of phenols from  Origanum dictamnus  L. and  Thymus vulgaris  L. against β-MgCA, among them I4-II7-di-carvacrol, a new natural product. Structure elucidation of the compounds was performed by 1 D, 2 D NMR and spectrometric analyses. Xanthomicrol and rosmarinic acid were active in the (sub)micromolar range (K IS  0.6 and 2.2 μM, respectively  vs  40.0 μM of the standard inhibitor acetazolamide). Finally, the compounds were not cytotoxic, but showed  in vitro  no activity against  Malassezia furfur .

Phenols from Origanum dictamnus L. and Thymus vulgaris L. and their activity against Malassezia globosa carbonic anhydrase