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Two new isocoumarins penicimarins L-M ( 1–2 ), along with seven known analogues ( 3–9 ) were isolated from the mangrove-derived fungus  Penicillium  sp. MGP11. Compounds  1 – 2  were established by spectroscopic methods and comparison of their circular dichroism (CD) spectra with the literature. All isolated compounds were evaluated for antioxidant and  α -glucosidase inhibitory activities. Compound  8  had better antioxidant activity (IC 50  = 4.6 μM) than positive control trolox (IC 50  = 12.9 μM). Compounds  5 ,  8  and  9  exhibited  α -glucosidase inhibitory activity with the IC 50  values of 776.5, 683.7 and 868.7 μM, respectively.

Bioactive isocoumarins isolated from a mangrove-derived fungus Penicillium sp. MGP11