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A chemical investigation of  Sigesbeckia glabrescens  Makino identified four compounds. On the basis of spectroscopic data, they were determined to be  ent -pimarane-type diterpenoids and their analogues, among which were two previously undescribed compounds, Sigesbeckia K ( 1 ) and Sigesbeckia L ( 2 ). The anti-inflammatory effects of these compounds were evaluated by testing their inhibition of LPS-induced NO production in BV2 microglial cells, which revealed potential inhibitory effects with IC 50  value at 62.56 μM and compared with the positive control minocycline (IC 50  32.84 μM).

Sigesbeckia K and L, two new diterpenoids from Sigesbeckia glabrescens with anti-inflammatory activity