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One new 3,5-dimethylorsellinic acid (DMOA)-based meroterpenoid ( 1 ), one prenylated tryptophan derivative ( 2 ), together with ten known compounds ( 3 − 12 ) were isolated from the endophytic fungus  Aspergillus  sp. from  Tripterygium wilfordii . Their structures and absolute configurations were determined by NMR spectroscopic data, HRESIMS data, UV and IR data as well as electronic circular dichroism (ECD) calculation. In structure, compound  1  was a rare example of DMOA-based meroterpenoid with a  cis -fused C/D ring system, and compound  2  possessed an unusual ( E )-oxime group. In bioactivity, the lovastatin analogues  5 ,  6 ,  9  and  10  showed potential immunosuppressive activity against anti-CD3/anti-CD28 monoclonal antibodies (mAbs)-irritated murine splenocytes proliferation, with IC 50  values ranging from (5.30 ± 0.51)  μ M to (16.51 ± 1.62)  μ M.

New secondary metabolites from the endophytic fungus Aspergillus sp. from Tripterygium wilfordii