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A new cyclo-heptadepsipeptide xanthostatin B ( 1 ), together with isobutyryl hexapeptide ( 2 ), xanthostatin ( 3 ), TXS-1 ( 4 ) and TXS-2 ( 5 ), were isolated from the marine sponge derived  Streptomyces  sp. SCSIO 40064. The structures were elucidated by comprehensive spectroscopic data analyses and comparison with the literatures. The D-Val unit in  1  was assigned by Marfey’s method. The absolute configuration of  4  was determined by X-ray crystallographic analysis. Compounds  1 ‒ 5  were evaluated for the inhibitory activities against four pharmaceutical targets and six antibacterial indicator strains. Compound  5  displayed  α -glucosidase inhibitory activity with IC 50  value of 18.67 ± 1.27 µM.

A new xanthostatin analogue from the marine sponge-associated actinomycete Streptomyces sp. SCSIO 40064