English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

A new diketopiperazine, cyclo-(d-8-acetoxyl-Pro-l-Leu) ( 1 ), together with eight known compounds ( 2 – 9 ) including three enterotoxins ( 2 – 4 ), four diketopiperazines ( 5 – 8 ) and maltol ( 9 ), were isolated from the mangrove derived-soil  Streptomyces  sp. SCSIO 41400. The planar structures of all compounds were determined from analysis of NMR spectra, MS, optical rotation and comparing with literature data. The absolute configuration of compound  1  was assigned by electronic circular dichroism (ECD). The isolated compounds ( 1 – 9 ) were tested for their acetyl cholinesterase (AChE) and pancreatic lipase (PL) enzyme inhibitory activities. Among them, the new diketopiperazine ( 1 ) displayed preferable PL enzyme inhibitory activity with IC 50  value of 27.3 μg/mL, while compounds  2 ,  5  and  6  showed weak PL enzyme inhibitory activity. Further molecular docking simulation exhibited that compound  1  could be well bind with the catalytic pocket of the PL. Besides, compound  9  showed moderate antibacterial activity against  Methicillin-resistant Staphylococcus aureus  with MIC value of 12.5 μg/mL, which was comparable to that of the positive control ampicillin with MIC value of 3.125 μg/mL.

Diketopiperazine and enterotoxin analogues from the mangrove derived-soil Streptomyces sp. SCSIO 41400 and their biological evaluation