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Two undescribed diarylheptanoids, 3-( R )-acetyl-1-(3′,4′-dihydroxyphenyl)-7-(4′′-hydroxy-3′′ -methoxyphenyl)-heptane ( 1 ) and 11-Hydroxy-1,17-epoxy-7-(2-hydroxylphenyl)-13-(16-methoxyphenyl)-heptane ( 2 ) together with known compounds, namely, 11-Oxo-1,17-epoxy-7-(2-hydroxylphenyl)-13-(16-methoxyphenyl)-heptane ( 3 ) 3,4,5-Trihydroxytetralone ( 4 ) 4,8- Dihydroxytetralone ( 5 ), 4,5-Dihydroxytetralone ( 6 ), 5,8-Dihydroxy-3-methoxytetralone ( 7 ) were isolated from ethyl acetate extract of the green husk of  Carya illinoinensis . The structures of compounds were established on the basis of IR,  1 H NMR,  13 C NMR, DEPT, HSQC, HMBC, COSY spectroscopic and ESI-MS analysis. The isolated compounds were evaluated for AChE (acetylcholinesterase inhibition) and observed that compound  5  was potent inhibitor with IC 50  of 101.48 ± 4.00 µg/mL.

Two undescribed diarylheptanoids from green husk of Carya illinoinensis as acetylcholinesterase inhibitors