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A new diterpenoid with an unusual capnosane skeleton, sinuhumilol A ( 1 ), alone with twelve known diverse compounds ( 2–13 ), were isolated from the South China Sea soft coral  Sinularia humilis.  Their structures and stereochemistry were elucidated by extensive spectroscopic analysis, quantum chemical calculations, and/or by the comparison of the spectroscopic data with those reported in the literature. In bioassay, compound  11  exhibited interesting specific cytotoxicity against the human colon adenocarcinoma cell line HT-29 with IC 50  value of 12.5  µ M.

Chemical constituents from the South China sea soft coral Sinularia humilis