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Two new chroman-4-ones penicichromanone A ( 1 ) and penicichromanone B ( 2 ), together with three known compounds conioxepinol C ( 3 ), emodin ( 4 ) and moniliphenone ( 5 ), were obtained from the endophytic fungus  Penicillium chrysogenum , which was isolated from the bark of  Eucommia ulmoides  Oliver. The structures of  1  and  2  were elucidated by detailed analysis of HRESIMS, 1D/2D NMR and ECD spectra. All the compounds were evaluated for their anti-inflammatory activities using HEK293 cells, and compounds  1 ,  3 ,  4  and  5  exhibited significant inhibitory effects on TNF- α -stimulated NF-κB activation.

Isolation and characterization of two new chroman-4-ones from the endophytic fungus Penicillium chrysogenum obtained from Eucommia ulmoides Oliver