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A new cassane diterpenoid, caesappine A ( 1 ), and a new natural cassane diterpenoid, caesappine B ( 2 ) were isolated from the seeds of  Caesalpinia sappan . The new structures of compounds  1  and  2  were elucidated by analysing their 1D NMR, 2D NMR and HR-ESI-MS spectra. Compounds  1  and  2  were evaluated for the cytotoxic activities on Hela and HepG-2 human cancer cell lines.

Two new cassane-type diterpenoids from the seeds of Caesalpinia sappan