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A new  N -methoxy-1-pyridone alkaloid [chromenopyridin A ( 1 )] and four known compounds ( 2 – 5 ) were isolated and identified from the endophytic fungus  Penicillium nothofagi  P-6, which was derived from the bark of the critically endangered conifer  Abies beshanzuensis . Their structures were elucidated by extensive spectroscopic analyses and single-crystal X-ray diffraction. Among the isolates, compound  1  showed considerable cytotoxicities against the A549 and Hela human cancer cell lines, with IC 50  values of 14.7 and 11.3 μM. In addition, compounds  1  and  4  exhibited potent antibacterial activity against  Staphylococcus aureus  with MIC values of 62.5 and 15.6 μg/mL, respectively.

natural product research

Chromenopyridin A, a new  N -methoxy-1-pyridone alkaloid from the endophytic fungus  Penicillium nothofagi  P-6 isolated from the critically endangered conifer  Abies beshanzuensis