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Three new diphenyl ethers, named praesorethers E, F and G ( 1 ,  2  and  3 ), were isolated from the lichen  Parmotrema praesorediosum . Their chemical structures were elucidated on the basis of extensively spectroscopic analysis including HR-ESI-MS and NMR as well as comparison with previously published data. These compounds were evaluated for the cytotoxicity against three human cancer cell lines (HeLa, NCI-H460 and MCF-7) using SRB assay. As results,  1  and  2  exhibited weak cytotoxic activity against three tested cancer cell lines with the inhibitive percentage of 64–79.9% at the concentration of 100 μg/mL while  3  was inactive.

Three new diphenyl ethers from the lichen Parmotrema praesorediosum (Nyl.) Hale (Parmeliaceae)