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Two new compounds, 6-acetyl-4-methoxy-3,5-dimethyl-2 H -pyran-2-one ( 1 ) and (2 E ,4 E )-5-((2 S ,3 S ,4 R ,5 R )-3,4-dihydroxy-2,4,5-trimethyltetrahydrofuran-2-yl)-2,4-dimethylpenta-2,4-dienal ( 2 ), and 22 known compounds were identified from the mangrove-forest-derived fungus  Penicillium polonicum  H175. The structures of these compounds were elucidated by analysis of the high-resolution electrospray ionisation mass spectroscopy (HR-ESI-MS), 1 D and 2 D nuclear magnetic resonance (NMR) data. The hypoglycaemic effect of compounds was evaluated by the Tg (Ins: htBidTE-ON; LR) zebrafish model. Compound  3  (aspterric acid) exhibited a significant hypoglycaemic effect equivalent to the positive drug rosiglitazone (RSG) at 10 μmol/L.

Two new compounds from a mangrove sediment-derived fungus Penicillium polonicum H175