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Chemical investigation of the roots of  Codonopsis javanica  resulted in isolation of 12 compounds, including one new polyacetylene, codojavanyol ( 1 ), one new phenolic glycoside, codobenzyloside ( 7 ), and 10 known compounds, (2 E ,8 E )-9-(tetrahydro-2 H -pyran-2-yl)nona-2,8-diene-4,6-diyl-1-ol ( 2 ), lobetyol ( 3 ), lobetyolin ( 4 ), lobetyolinin ( 5 ), cordifolioidyne B ( 6 ), benzyl- α -L-arabinopyranosyl (1-6)- β -D-glucopyranoside ( 8 ), ( Z )-8- β -D-glucopyranosyloxycinnamic acid ( 9 ), syringin ( 10 ), syringaresinol ( 11 ), and tryptophan ( 12 ). Their structures were elucidated by 1 D and 2 D NMR and MS spectroscopic analyses in comparison with the data reported in the literature. The stereochemistry of the C-2′ position of  1  was identified based on time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) calculation. Among the isolates, compounds  3-5  were shown to have weak cytotoxicity toward three human carcinoma cell lines, including lung (A549), liver (HepG2), and breast (MCF7), with the induction of 41.4 to 55.6% cell death at the concentration of 100 µM.

Polyacetylene and phenolic constituents from the roots of Codonopsis javanica