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A new dimeric monoterpene indole alkaloid polonidine A ( 1 ), along with five known compounds, cyclopenol ( 2 ), verrucosidin ( 3 ), fructigenine A ( 4 ), 3-O-methylviridicatin ( 5 ) and aurantiomides C ( 6 ), were isolated from  Penicillium polonicum  TY12. Their structures were established on the basis of extensive spectroscopic analyses. Compound  1  exhibited moderate cytotoxic activities and moderate antibacterial activity against  Bacillus subtilis  with MIC of 4.0 μg/mL.

A new cytotoxic indole alkaloid from the fungus Penicillium polonicum TY12