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A new coumarin named (9 R, 10 R)-9, 10-dihydro-10-hydroxy-9-methoxy-bergapten ( 1 ) and 13 known compounds ( 2–14 ) were isolated from the roots of  Heracleum dissectum  Ledeb., in which compounds ( 2–13 ) were obtained from  H. dissectum  for the first time. Their structures were illuminated by HR-ESI MS, 1 D and 2 D NMR, optical rotation and comparison with literatures. All compounds were evaluated against hepatocellular carcinoma HepG2 cell lines and the results showed that candinol C ( 8 ) had moderate cytotoxic activity against HepG2 cells with IC 50  value at 57.6 ± 1.1 µM.

A new coumarin isolated from the roots of Heracleum dissectum Ledeb