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A new tetracyclic depsidone derivative, guanxidone A ( 1 ), together with three known metabolites  2 – 4 , was isolated from the mangrove endophytic fungus  Aspergillus  sp. GXNU-A9. The structure of compound  1  was established by HR-ESI-MS, 1 D and 2 D NMR data, as well as by comparison with literature data. Compounds  1 – 4  were evaluated for their anti-inflammatory effects on the production of the nitric oxide (NO), and compound  1  significantly reduced the production of NO in lipopolysaccharide (LPS)-stimulated cells with IC 50  value of 8.22  µ M.

A new depsidone derivative from mangrove endophytic fungus Aspergillus sp. GXNU-A9