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Two new lanostane triterpnenoids named endertiins A and B ( 1  and  2 ) together with two known compounds as ganodecalone A ( 3 ) and ergosterol ( 4 ) have been successfully isolated from the cultivated fruit bodies of the mushroom  Humphreya endertii  Stey (Ganodermataceae). Their structures were elucidated by a combination of HR-MS and 2 D NMR spectroscopic analyses. In addition, endertiins A and B ( 1  and  2 ) were evaluated their cytotoxicity against two cancer cell lines, MCF7 (human breast carcinoma) and LU (human lung carcinoma). The result showed that endertiin A ( 1 ) could inhibit the growth of MCF-7 cells with its IC 50  value of 71.16 ± 6.25 µg/ml.

Endertiins A-B, two lanostane triterpenoids from the fruit bodies of the mushoom Humphreya endertii