English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Series of thioether derivatives containing 4-methylumbelliferone fused oxazole moiety were designed and synthesised, their structures were fully characterized by  1 H NMR,  13 C NMR and HR-ESI-MS as well. Moreover, the  in vitro  antifungal potency of the title compounds were preliminarily evaluated for their possible use as a fungicide. Meanwhile, ethyl thioethers  3aa  and  3ba  displayed remarkable inhibitory effect against the mycelium growth of  Valsa mali  and  Botrytis cinerea  with EC 50  of 12–16 μg/mL. Furthermore, compounds  3aa  and  3ba  also exhibited &gt; 88% protective and curative effect against  B. cinerea  on tomato fruits at 90 μg/mL. Additionally, the environmental toxicity of the title compounds against the brine shrimp  Artemia salina  were evaluated as well. The results indicated that most of the title compounds exhibited weak toxic to aquatic organism  A. salina.

4-Methylumbelliferone fused oxazole thioether derivatives: synthesis, characterization and antifungal activities