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In this work,  n -hexane, chloroform, and ethyl acetate fractions of the methanol extract of  Myristica fragrans  Houtt. seeds were evaluated against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)  via  Ellman’s method. It was found that all fractions depicted no anti-AChE activity, however, they were active toward BChE with IC 50  values of 361.8, 215.0, and 145.8 µg/mL, respectively comparing with donepezil as the reference drug (IC 50  = 1.97 µg/mL). The ethyl acetate fraction which also showed high neuroprotectivity and metal chelating ability was selected for the phytochemical analysis. Our results confirmed the presence of trimyristin and 5,7-diacetyl chrysin (reported for the first time in  M. fragrans ) in the corresponding fraction.

Phytochemical investigation and anticholinesterase activity of ethyl acetate fraction of Myristica fragrans Houtt. seeds