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Previous studies have detected the association of polymorphisms in oxidative stress-related genes  EPHX1  and  MnSOD  with pre-eclampsia (PE) risk, but the results are inconsistent among studies. Thus, a meta-analysis was performed to obtain more conclusive results. Eligible studies were retrieved in PubMed, Web of Science, EMBASE, Scopus, and CNKI. Odds ratios (ORs) with 95% confidence intervals (CIs) were utilized to evaluate the relationship between  EPHX1  rs1051740,  EPHX1  rs2234922,  MnSOD  rs4880 polymorphisms, and PE susceptibility in the genetic models. The subgroup analysis was also performed. Fourteen studies with a total of 4250 participants were included, including 1784 PE patients and 2466 healthy women. There was a statistically significant association between  EPHX1  rs1051740 polymorphism and PE in Caucasians within the allele, dominant, heterozygous, and homozygous models (OR = 0.79, 95% CI = 0.64–0.98; OR = 0.64, 95% CI = 0.47–0.87; OR = 0.61, 95% CI = 0.44–0.85; OR = 0.63, 95% CI = 0.42–0.97, respectively). There was a statistically significant association between  EPHX1  rs2234922 polymorphism and PE in Middle Easterners within the recessive and homozygous models (OR = 3.59, 95% CI = 1.25–10.32; OR = 3.99, 95% CI = 1.38–11.49, respectively). There was no statistically significant association between  MnSOD  rs4880 polymorphism and PE within five genetic models. Subgroup analysis didn’t reveal any association between  MnSOD  rs4880 polymorphism and PE in Asians, Caucasians, or Middle Easterners. This meta-analysis shows a significant association between the  EPHX1  rs1051740 and PE risk in Caucasians. Meantime, there was a statistically significant association between  EPHX1  rs2234922 polymorphism and PE in Middle Easterners.

Oxidative stress-related genes ( EPHX1 and MnSOD) polymorphism and risk of pre-eclampsia: a meta-analysis