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Gestational diabetes mellitus (GDM) is characterized as a common metabolic disorder during pregnancy which is associated with glucose intolerance and insulin resistance. Genetic predisposition could contribute to the development of GDM. We conducted a case-control study to inspect the impact of GSTM1 and GSTT1 polymorphism on GDM susceptibility in Iranian population. The population consisted of 149 pregnant women with GDM as cases, and 138 healthy pregnant women without any history of GDM as controls. Polymerase chain reaction-restriction fragment length polymorphism method was applied to determine the GSTM1 and GSTT1 gene polymorphisms. There were statistically significant differences between the cases and controls in terms of age ( p  = .005), BMI ( p  &lt; .001), family history of gestational diabetes ( p  &lt; .001), FBS ( p  = .001), TG ( p  ≤ .001), and HDL ( p  = .003). However, no significant differences were observed in TC ( p  = .078) and LDL ( p  = .062). There were significant differences between GSTM1 polymorphism (Null and present) in the case and controls groups [OR (95% CI); 2.3 (1.4–3.7),  p  &lt; .001]. The distribution of GSTM1-null genotype was found to be significantly higher in GDM patients (68.6%) than the control group (48.5%). No significant variance was detected between GSTT1 polymorphism (Null and present) in the case and controls groups [OR (95% CI); 1.1 (0.6–1.6),  p  = .088]. The frequency of GSTM1 null/GSTT1 null [OR (95% CI); 2.7 (1.2–5.2),  p  = .01] and GSTM1 null/GSTT1 present [OR (95% CI); 2.6 (1.4–4.8),  p  = .002] genotypes significantly differed between the GDM and control groups. It seems that GSTM1 null genotype might be considered as GDM risk factor in Iranian population.

The impact of GSTM1 and GSTT1 polymorphisms on susceptibility to gestational diabetes in Iranian population