English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The present study aims at the evaluation of  in vitro  and  in vivo  toxicities of green TiO 2  nanoparticles (GS-TiO 2 ) that are biosynthesised using hydroalcoholic extract of  Ocimum sanctum  leaves using microwave energy. Commercially available TiO 2  NPs (CS-TiO 2 ) were used for comparison. In vitro hemotoxicity was evaluated using haemolysis assay, and viability of fibroblast cells using WST-8 assay. In vivo toxicity evaluation was performed using the silkworm model. Haemolysis assay showed that GS-TiO 2  caused acceptable haemolysis of 2.3% and CS-TiO 2  showed higher haemolysis of 4.4%. As per WST-8 assay, viability of fibroblast cells was better in groups treated with GS-TiO 2  with more than 50% survival. Silkworm growth parameters were significantly improved in GS-TiO 2 -treated batches. At the biomolecular level, changes in haemolymph protein banding patterns indicated strong growth promoting potential of GS-TiO 2 . Considering the salient findings derived from toxicity results, we propose that GS-TiO 2  shall be potent NPs for various biomedical applications.

In vitro and in vivo toxicological evaluation of green synthesised anatase TiO 2 nanoforms