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Cordyceps militaris  and  Isaria tenuipes  (Cordycipitaceae) are high-value fungi that are used for health-promoting food supplements. Since laboratory cultivation has begun for these fungi, increased output has been achieved. This study compared the chemical profiles, antioxidant, anti-tyrosinase, and skin extracellular matrix degradation inhibition between mycelium and fruiting body of  C. militaris  and  I. tenuipes . The antioxidative potential of 10% v/v aqueous infused extract from each fungus was separately investigated using 2,2-azinobis(3-ethylbenzo-thiazoline-6-sulphonic acid) (ABTS), 1,1-diphenyl-2-picrylhydrazyl (DPPH), ferric reducing antioxidant ability, and ferric thiocyanate methods. The inhibition against MMP-1, elastase, and hyaluronidase were determined to reveal their anti-wrinkle potential. Anti-tyrosinase activities were determined. C. militaris  and  I. tenuipes  extracts were found to contain a wide range of bioactive compounds, including phenolics, flavonoids, and adenosine. A correlation was discovered between the chemical compositions and their biological activities. The extract from  I. tenuipes  fruiting body (IF) was highlighted as an extraordinary elastase inhibitor (IC 50  = 0.006 ± 0.004 mg/mL), hyaluronidase inhibitor (IC 50 : 30.3 ± 3.2 mg/mL), and antioxidant via radical scavenging (ABTS IC 50 : 0.22 ± 0.02 mg/mL; DPPH IC 50 : 0.05 ± 0.02 mg/mL), thereby reducing ability (EC 1 : 95.3 ± 4.8 mM FeSO 4 /g extract) and lipid peroxidation prevention (IC 50 : 0.40 ± 0.11 mg/mL). IF had a three-times higher EC 1  value than ascorbic acid and significantly higher elastase inhibition than epigallocatechin gallate. IF is proposed as a powerful natural extract with antioxidant and anti-wrinkle properties; therefore, it is suggested for further use in pharmaceutical, cosmeceutical, and nutraceutical industries.

pharmaceutical biology

Comparison of chemical profiles, antioxidation, inhibition of skin extracellular matrix degradation, and anti-tyrosinase activity between mycelium and fruiting body of  Cordyceps militaris  and  Isaria tenuipes