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Delphinidin-3- O -glucoside (DP) is a bioactive compound of  Hibiscus sabdariffa  L. (Malvaceae) (Roselle) calyces and exerts endothelial protection and lipid-lowering activities, which provided a basis for the prevention and treatment of cardiovascular diseases. To investigate the therapeutic effects of DP against atherosclerosis. A rabbit model of atherosclerosis (AS) was established by 12 weeks of a high-fat diet (HFD). The rabbits were divided into five groups: control, AS, simvastatin (4 mg/kg), and two DP groups (10 and 20 mg/kg). After treatment with DP or simvastatin by oral gavage for 12 weeks, the lipid profiles were measured. Histopathological assessment of the aorta was performed by H&amp;E staining. Oxidative stress and inflammation-related markers were analyzed by ELISA kit and real-time RT-PCR. DP (20 mg/kg) decreased serum TG (2.36 ± 0.66  vs.  4.33 ± 0.27 mmol/L for the AS group), TC, LDL-C, and HDL-C (all  p  &lt; 0.05). DP (20 mg/kg) also reduced lipid levels in the liver and aorta. DP (20 mg/kg) down-regulated the mRNA levels of IL-6, VCAM-1, and NF-κB and up-regulated the mRNA levels of GSH-PX and SOD1. This study proved that DP alleviated the HFD-induced oxidative stress and inflammation in atherosclerosis rabbits. These results provided the scientific basis for developing novel therapies.

pharmaceutical biology

Delphinidin-3- O -glucoside, an active compound of  Hibiscus sabdariffa  calyces, inhibits oxidative stress and inflammation in rabbits with atherosclerosis