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This study aimed to determine the effect of  Bacillus Coagulans  symbiotic supplementation on metabolic factors and inflammation in patients with type-2 diabetes. In this clinical trial, 50 patients with type-2 diabetes were randomly assigned to the symbiotic (containing  Bacillus Coagulans  +  Lactobacillus rhamnosus  +  Lactobacillus acidophilus  and fructooligosaccharide) or placebo groups to receive one sachet daily for 12 weeks. Glycaemic Index, lipid profile, and hs-CRP were measured at the beginning and end of the study. Analysis of covariance demonstrated that fasting blood glucose (FBG), insulin, homeostatic Model Assessment for Insulin Resistance (HOMA-IR), β-cell function (HOMA-β) ( p  &lt;.05) and hs-CRP ( p  &lt;.05) significantly declined in the treatment group compared with the placebo group. So, the current study indicated that  Bacillus Coagulans  symbiotic supplementation could improve metabolic factors and inflammation in patients with type-2 diabetes.

archives of physiology and biochemistry

Does symbiotic supplementation which contains  Bacillus Coagulans Lactobacillus rhamnosus, Lactobacillus acidophilus  and fructooligosaccharide has favourite effects in patients with type-2 diabetes? A randomised, double-blind, placebo-controlled trial