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This study was designed to investigate whether the glucose lowering effects of  Potentilla fulgens  acts by modulating GLUT4, AKT2 and AMPK expression in the skeletal muscle and liver tissues. Alloxan-induced diabetic mice treated with  Potentilla fulgens  was assessed for their blood glucose and insulin level, mRNA and protein expression using distinguished methods. Additionally, GLUT4, AKT2 and AMPK were docked with catechin, epicatechin, kaempferol, metformin, quercetin and ursolic acid reportedly present in  Potentilla fulgens . Potentilla fulgens  ameliorates hyperglycaemia and insulin sensitivity via activation of AKT2 and AMPK, increases the expression of GLUT4, AKT2, AMPKα1 and AMPKα2 whose levels are reduced under diabetic condition. Molecular docking revealed interacting residues and their binding affinities (−4.56 to −8.95 Kcal/mol). These findings provide more clarity vis-avis the mechanism of action of the phytoceuticals present in  Potentilla fulgens  extract which function through their action on GLUT4, PKB and AMPK.

Potentilla fulgens upregulate GLUT4, AMPK, AKT and insulin in alloxan-induced diabetic mice: an in vivo and in silico study