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This study aimed to elucidate the effects of grape seed proanthocyanidin extract (GSPE) on oxidative stress (OS), antioxidant enzymes, free radicals and cytokines in the pancreas of T1DM rats. Two-month-old Wistar rats were assigned to the control (CON), CON + GSPE (CON + PA), diabetics (STZ, 60 mg/kg b.w.), diabetes + GSPE (STZ + PA), diabetes + insulin (STZ + INS, 3 U/day) and diabetics + GSPE and INS (STZ + INS + PA) groups. GSPE (75 mg/kg b.w.) was administered daily either alone or with INS for 8 weeks. Glutathione was lowest in diabetics while it increased in the STZ + INS + PA ( p  &lt; .001) group, similar to catalase activity ( p  &lt; .05). Hydrogen peroxide, superoxide and lipid peroxidation increased with iNOS, TNF-α and IL-1β in the diabetic pancreases, while GSPE decreased ( p  &lt; .001). Further, reduced β-cells/islet number was improved in diabetics ( p  &lt; .001) with treatment. This study suggests that GSPE with INS is effective in minimising OS and pancreatic degeneration in T1DM rats.

Grape seed proanthocyanidin extract suppresses oxidative stress in the rat pancreas of type-1 diabetes