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The antidiabetic potentials of the dichloromethene, ethyl acetate, butanol and aqueous fractions of  Bridelia ferruginea  leaves were investigated using  in vitro ,  ex vivo  and  in vivo  models.  In vitro  and  ex vivo  antidiabetic activities revealed the butanol (BFBF) to be the most active of the fractions, and thus selected for  in vivo  study. Diabetes was induced using the fructose-streptozotocin model. Treatments with BFBF significantly reduced blood glucose level and improved glucose tolerance, serum insulin level and sensitivity as well as suppressed hyperlipidaemia and serum nephropathy markers. Histopathological analysis revealed the ability of BFBF to protect and regenerate pancreatic β-cells. BFBF significantly elevated glutathione level, catalase and superoxide dismutase activities, while depleting MDA level in serums and kidney of diabetic rats. Phenols, steroids, terpenoids, aliphatic and aromatic compounds were identified in the fractions following GC-MS analysis. Overall, results from this study propose that BFBF possess potent antidiabetic activity.

Bridelia ferruginea inhibits key carbohydrate digesting enzyme and intestinal glucose absorption and modulates glucose metabolism in diabetic rats