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The present investigation was aimed to study the anti-diabetic and hypolipidemic potential of  Cinnamon cassia  (Lauraceae family) bark in streptozotocin (STZ)-induced diabetic rats. The preliminary phytochemical analysis (hexane, petroleum ether, chloroform, ethanol, methanol, and aqueous extracts), GC-MS analysis (ethanol),  in vitro  (aqueous, ethanol and methanol),  in vivo  (ethanol) and  in silico  anti-diabetic activity with hypolipidemic effect of  C. cassia  bark was analysed. The ethanolic extract of the  C. cassia  bark has a fine inhibitory activity than the aqueous and methanolic extract. Out of 20 different compounds identified, seven compounds were biologically active, and 9-octadecenoic acid has highly interacted with PPARα/γ in docking studies. The levels of diabetic markers, enzymes, and lipid profiles were altered in STZ-induced rats, but after the treatment of  C. cassia , the levels were returned to the normal. The study may prove the ethanolic extract of  C. cassia  has a powerful anti-diabetic and anti-hyperlipidemic activity.

Anti-diabetic and hypolipidemic effects of Cinnamon cassia bark extracts: an in vitro , in vivo , and in silico approach