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To investigate the association of polymorphisms in  SLC6A4  and  MAOA  genes with obesity indices in children. A total of 637 Portuguese children (317 girls; 320 boys) aged 3–11 years-old were genotyped for the  SLC6A4  polymorphisms, 5-HTTLPR and STin2, and for a  MAOA  VNTR. Polymorphisms were analysed by PCR-based methods. Although non-significant ( p  = .089), our study revealed the Stin2 10 minor allele with a marked higher frequency in girls with overweight/obesity (0.466) in comparison with controls (0.376). Combining the two  SLC6A4  polymorphisms, haplotype S/12 revealed in girls significant or nominally significant protective effects against BMI (β = −0.615;  p  = .009), BMI Z-score (β = −0.251;  p  = .006), WC (β = −1.4;  p  = .02) and WHtR (β = −0.008;  p  = .04). We found some evidences for the role of  SLC6A4  gene in measures of childhood obesity, mainly in girls.

Association study of common functional genetic polymorphisms in SLC6A4 (5-HTT) and MAOA genes with obesity in portuguese children