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Context:  Studies have shown that cardiac triglyceride accumulation and impaired Na + -K + -ATPase activity are linked to diabetes- related cardiovascular disease, particularly in women. Objectives:  We hypothesised that allopurinol (ALL) and valproic acid (VPA) treatment would improve cardiac triglyceride and Na + -K + -ATPase activity independent of circulating aldosterone in Combined Oral Contraceptive (COC)-induced dysglycemia Materials and methods:  Rats received COC (1.0 μg ethinylestradiol and 5.0 μg levonorgestrel;  po ) with or without ALL (1 mg;  po ) and VPA (20 mg;  po ) for 6 weeks. Results:  COC-treatment led to impaired glucose tolerance, accumulated abdominal fat, dyslipidemia, elevated plasma MDA, PAI-1 and aldosterone levels and also reduced plasma nitric oxide bioavailability and cardiac Na + -K + -ATPase activity. However, either ALL or VPA treatment ameliorated these alterations comparably independent of elevated aldosterone level Discussion and conclusion:  Our results suggest that either ALL or VPA would improve cardiac TG and Na + -K + -ATPase activity comparably in COC-treated rats, regardless of circulating aldosterone level.

archives of physiology and biochemistry

Allopurinol and valproic acid improve cardiac triglyceride and Na + -K + -ATPase activity independent of circulating aldosterone in female rats with glucose intolerance