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Background:Moringa oleifera  Lam. has been used traditionally for the treatment of different cardio-metabolic disorders. So, the aim was to assess its leaf extracts in metabolic syndrome rat model. Methods:  Out of the total 36-rats, 6 rats were given normal matched diet (NMD) while the rest were provided high-fat diet and 20% fructose (HFD-20%F).  Moringa oleifera  leaf extracts were administered orally for 30 days. Body weight, blood glucose, BMI, blood pressure, lipids, insulin, insulin resistance, MCP-1, visceral fat and liver weight were evaluated. Results:  Sixty-days feeding with HFD-20%F produced the metabolic syndrome features like hyperinsulinemia, insulin resistance, and increase in low-density lipoprotein (LDL), visceral fat, and liver weight significantly ( p &lt;.05) than the rats receiving (NMD).  Moringa oleifera  treatment for 30 days significantly provided the mitigation against metabolic syndrome features. Conclusion:Moringa oleifera  Lam. leaf extract might be a good alternative herbal choice in the treatment of metabolic syndrome disease.

Moringa oleifera Lam. leaf extracts reverse metabolic syndrome in Sprague Dawley rats fed high-fructose high fat diet for 60-days