English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Objective:  To explore the probable  in vitro, in situ  and  in vivo  mechanisms of gallic acid (GA) and  p -coumaric acid (PCA) as anti-hyperglycemic agents. Animals and methods:  Male albino rats were allocated into four groups, group1 was used as normal control. Group 2 was established as a diabetic control and group3 and 4 were treated with an oral dose of GA and PCA, respectively. Results:  GA and PCA revealed a significant decrease in the activity of α-amylase, a noticeable rise in glucose induced-insulin secretion and glucose-uptake in peripheral glucose-uptake  in vitro , increase also liver glycogen and serum insulin levels  in vivo . Further, GA and PCA exhibited a significant reduction in intestinal glucose absorption  in situ  compared to blank. Conclusion:  The antihyperglycemic activities of GA and PCA can be mediated through delaying intestinal glucose absorption, enhancing β-cell activity and promoting glucose uptake by peripheral tissue  via  enhancing insulin sensitivity.

New insights into the in vitro , in situ and in vivo antihyperglycemic mechanisms of gallic acid and p -coumaric acid