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We investigated the effects of high-fat diet (HFD) consumption combined with diabetes induction, resistance exercise training (RET) and a de-training period on circulating irisin levels and selective metabolic parameters. Rats were assigned to four groups ( n =  8): healthy non-diabetic rats (NDC), non-diabetic rats that performed RET (NDR), sedentary HFD-fed/STZ-treated rats (HFD/STZ) and HFD-fed/STZ-treated rats that performed RET (HFD/STZ + RE). HFD consumption reduced irisin level and Quicki ( p  &lt; .01). After the 12-week period, levels of TC, TG, HOMA1-IR, HOMA2-IR and irisin were also lower in the HFD/STZ + RE group compared to the HFD/STZ group. Body weight and HOMA1-IR showed a positive ( r =  0.558 and  r =  0.538) whereas TC and LDL-C had a negative correlation ( r  = −0.461 and  r  = −0.630) with irisin level ( p  &lt; .05). Irisin level increased along with the progress of obesity and T2DM. It seems that RET can attenuate the increase of irisin in those conditions by improvement of glucose/lipid metabolic disorders.

The effects of resistance exercise training followed by de-training on irisin and some metabolic parameters in type 2 diabetic rat model