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We aimed to compare the electrocardiographic parameters in patients with methamphetamine use to healthy controls. The study is a cross-sectional case-control study. Sixty-eight patients diagnosed with methamphetamine use disorder (MUD) according to DSM-5 criteria and 65 subjects in healthy control group who can match the patient group with demographic data were included in the study. Heart rate, P wave dispersion, QT dispersion, QTc and Tp-e/QTc ratios were calculated in the ECGs of all participants. The mean age of the patients was 25.60 ± 5.70 and of the control group was 27.43 ± 6.10 ( p  = 0.076). There was no statistically significant difference between the blood pressure, body mass index, HDL-LDL-total cholesterol and triglyceride values of the participants ( p  &gt; 0.05). Although QT dispersion was 13.68 ± 9.12 in patients with methamphetamine use disorder, it was calculated as 9.08 ± 7.85 in the control group ( p  = 0.002). Finally, the Tp-e/QTc ratio of the patients was higher than the healthy controls ( p  = 0.014). In our study, we found a significant deterioration in QT dispersion and Tp-e/QTc ratio in the MUD group. Therefore, it should be kept in mind that there is a risk of malignant arrhythmia in this patient group and care should be taken in terms of arrhythmic events during follow-up in this patient group.Key pointsPatients with methamphetamine use showed significant deterioration in QTd and Tp-e/QTcMethamphetamine users have prolonged Tp-e/QTc ratio and QTdCaution should be exercised in terms of arrhythmic events in methamphetamine users Patients with methamphetamine use showed significant deterioration in QTd and Tp-e/QTc Methamphetamine users have prolonged Tp-e/QTc ratio and QTd Caution should be exercised in terms of arrhythmic events in methamphetamine users

The effects of methamphetamine on electrocardiographic parameters in male patients