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Current international guidelines strongly advise endoscopic submucosal dissection (ESD) instead of endoscopic mucosal resection (EMR) for the endoscopic resection of sessile colorectal tumours &gt;20 mm. To compare the safety and efficacy of EMR and ESD for treating large non-invasive colorectal lesions. We performed a systematic review using electronic databases (MEDLINE/PubMed, EMBASE, and Cochrane Library) on February 21st, 2021 and a meta-analysis to assess en-bloc and R0 rates, and related adverse events. Twenty-four studies were included, comparing 3,424 ESD and 5,122 EMR procedures. The en-bloc resection rate was 90.8% in the ESD and 33.0% in the EMR group ( p  &lt; .001). The R0 resection rate was 85.0% in the ESD and 64.6% in the EMR group ( p  = .005). The rate of perforation was 5.1% in the ESD and 1.67% in the EMR group ( p  &lt; .001). The bleeding rate was 4.3% in the ESD and 3.6% in the EMR group ( p  = .008). The overall need for surgery, including oncologic reasons and complications, was 5.9% in the ESD and 3.1% in the EMR group ( p  &lt; .001). ESD for large non-pedunculated colorectal lesions allows a higher rate of R0 resections than EMR, at the cost of a higher perforation rate and the need for additional surgery.

minimally invasive therapy and allied technologies

A systematic review and meta-analysis of endoscopic mucosal resection  vs  endoscopic submucosal dissection for colorectal sessile/non-polypoid lesions