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This study aimed to assess resilience and its relationship with occupational stress (OS) and PQOL among nurses in COVID-19 isolation wards. This is a descriptive-analytical research design involving 158 frontline nurses in the Iran. Four standardized scales were used for data collection. The total mean scores of resilience and OS were 26.19 ± 6.2 and 73.3 ± 14.5, respectively. The mean scores of participants’ resilience and OS had no significant relationship with their demographic characteristics (P &gt; 0.05). Resilience had significant negative relationship with OS (r = – 0.376, P &lt; 0.001) and significant positive relationship with the compassion satisfaction dimension of PQOL (r = 0.373; P &lt; 0.001). Resilience was also a significant predictor of OS and the compassion satisfaction dimension of PQOL (P &lt; 0.001). Nurses’ OS can be reduced through resilience-promoting strategies such as development of their social support network, improvement of their optimism, and provision of resilient role models and quality resilience-related education.

Resilience and its relationship with occupational stress and professional quality of life during COVID-19 pandemic