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Cobalt chloride-(CoCl 2 ) exerts beneficial and toxic activities depending on dose however Naringenin-(Nar) a flavonoid, chelates heavy metals. Absorption of ingested heavy metals, or chelates are dependent on gut motility (gastric emptying and intestinal transit time) and mechanosensor regulation. Literature is vague on CoCl 2  activities on gut motility and mechanosensor nor probable chelating actions with naringenin which was investigated in this study. Method One hundred male Wistar rats were grouped viz; A to D (25, 62, 150 and 300 mg/kg CoCl 2 ), E to H doses of CoCl 2 +Nar (50 mg/kg), I-Narigenin and J-Control. Gastric emptying and intestinal transit time were evaluated by day eight, intestinal tissue assayed for biochemical, histological and immunohistochemistry reactivity. Result CoCl 2  significantly increased Gastric emptying (150 and 300 mg/kg) and Intestinal transit time unlike Naringenin. CoCl 2  (150 mg/kg) significantly increased Catalase and Nitric oxide but ameliorated by Naringenin. ATPase activities significantly increased in 150 mg/kg-CoCl 2  but ameliorated by Naringenin. Carbonyl levels increased in all CoCl 2 +Nar groups. High Enterochromaffin-cell count in 25 and 62 mg/kg-CoCl 2  were ameliorated by Naringenin. Serotonin immunoreactivity increased in CoCl 2  (25, 62, 300 mg/kg) but reduced in CoCl 2 +Nar groups. Conclusion Cobalt chloride enhanced gastric motility via increased mechanosensor activities and serotonin expression at low doses. Naringenin ameliorated toxicity of high cobalt chloride via metal-flavonoid chelates.

Naringenin modulates Cobalt activities on gut motility through mechanosensors and serotonin signalling