English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Pancreatic islet β-cells weaken under oxidative stress. In this study, human pancreatic islet-derived 1.1B4 cells were exposed to H 2 O 2  and analysed using a human microarray, which revealed that  heme oxygenase 1  ( HMOX1) ,  glutamate-cysteine ligase ,  early growth response 1 ,  nuclear receptor subfamily 4 group A member 3  ( NR4A3 ) and  jun B proto-oncogene  were upregulated, whereas  superoxide dismutase 1  and  catalase  were not. Expression of  NR4A3  rapidly increased after H 2 O 2  addition, and the 1.1B4 cells treated with siRNA targeting  NR4A3  became sensitive to H 2 O 2 ; further,  HMOX1  expression was strongly inhibited, suggesting that  NR4A3  is an oxidative stress-responsive transcription factor that functions through  HMOX1  expression in pancreatic islet β-cells. Expression of  cyclin E1  and  cyclin-dependent kinase 1  was also inhibited by siRNAs targeting  NR4A3 .

redox report

Analysis of an antioxidative defence system of hydrogen peroxide-treated pancreatic islet-derived 1.1B4 cells and siRNA targeting NR4A3-treated cells by microarray