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The aim of this work was to evaluate the antifungal and antiparasitic activity of roots of  Wunderlichia azulensis  (Asteraceae). A CH 2 Cl 2  partition of  W. azulensis  was tested against  Candida tropicalis ,  C. buinensis  and  Trypanosoma cruzi  parasites. A chemical study of the CH 2 Cl 2  partition resulted in the isolation and identification of dehydrobrachylaenolide ( 1 ), lasiodiplodin ( 2 ), a taraxerane-type triterpene ( 3 ) and a mixture of sitosterol and stigmasterol ( 4–5 ). Of the 13 fractions tested, fractions 5 and 7 were the most bioactive ones. No live epimastigotes were observed even after the shortest time of exposure to fraction 7 (25 μg.mL −1 /24 h). Fractions 5 and 7 inhibited yeast growth in proportions between 63.9–80.7% at 50 μg.mL −1 , and 70.3–96.7% at 100 μg.mL −1 . Fractions 5 and 7 (100 μg.mL −1 ) induced loss of viability of  C. buinensis  by 97.61 and 92.63%, respectively, whereas  C. tropicalis  was less susceptible. The SYTOX Green marker used on  Candida  yeasts suggested membrane permeabilization and consequently plasma membrane damage. We concluded that  W. azulensis  offers new sources of biologically-active components. However, complementary studies on other variables, such as synergy, toxicology, and mechanism of action, must be carried out.

Antifungal and antiparasitic activity of Wunderlichia azulensis (Asteraceae) roots