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Helianthemum lippii  is a perennial shrubby plant growing in the sandy environments of Italy, Mediterranean countries of North Africa and Middle East.  H .  lippii  is used in traditional medicine but there are very few reports referring to the phytochemical characterization, the ethnopharmacology, and the biological activity of  H. lippii . The goal of this study was to determine the phytochemical composition of different H. lippii extracts, cold (CME) and hot (HME) methanol, cold (CPEE) and hot (HPEE) petroleum ether, as well as to evaluate their anticancer and antimicrobial activities and biofilm formation reduction. Fifty-fours phytocompounds have been determined by HPLC-UV-ESI-QTOF-MS analysis. All the four extracts reduced the viability of human MDA-MB231 and HCT116 cells, being cold and hot methanol extracts the most effective. The antimicrobial activity against  S. aureus ,  P. aeruginosa ,  E. faecalis ,  E. coli ,  C. albicans  was also evaluated. Data showed the greater susceptibility of  S. aureus  to hot methanolic extract. Concerning antifungal activity,  C. albicans  resulted more susceptible to petroleum ether. Moreover, some of the samples exhibited a good antibiofilm activity both on immature and on mature biofilms. The four extracts showed interesting antimicrobial and cytotoxic activities and can be considered good candidates for new therapeutic applications

Phytochemical-rich extracts of Helianthemum lippii possess antimicrobial, anticancer, and anti-biofilm activities