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This study aimed to assess the effects of nutritional intervention in breast cancer patients. Anthropometrics serum biomarkers and tumor markers were assessed in breast cancer female patients. Product intervention was done in the breast cancer group ( n  = 120) which was further segregated into three treatments groups T 0  placebo Group (non-supplemented cookies) + chemotherapy, T 1  synthetic group (vitamin D and calcium supplement) + chemotherapy, T 2  natural group (ESP + CLO supplemented cookies) + chemotherapy. Anthropometrics data showed that body mass index (BMI) and hand grip strength (kg) were varied from 26.48 ± 0.28 to 26.15 ± 0.20 kg/m 2  and 22.18 ± 0.36 to 22.21 ± 0.38 kg among T 2  group, respectively. After intervention of natural supplement, serum calcium and serum vitamin D levels were significantly improved from 8.45 ± 0.08 to 8.61 ± 0.11 mg/dl and 26.45 ± 0.84 to 30.33 ± 1.37 ng/ml among T 2  participants, respectively. Whereas in T 1  group the serum calcium slightly improved from 8.46 ± 0.06 to 8.53 ± 0.07 mg/dl and serum vitamin D levels enhanced from 24.18 ± 1.06 to 26.38 ± 1.05 ng/ml among participants. The serum parathyroid hormone level significantly decreased from 5.2 ± 0.07 to 4.9 ± 0.07 pmol/l in T 2  group participants. The nutritional intervention of calcium and vitamin D had shown to improved body mass index (BMI), hand grip strength and increased oral intake in patients and reduced inflammatory markers. Chemotherapy-induced dietary issues may be managed by effective oral nutritional intervention. Serum calcium and vitamin D may be modifiable factor for the risk of breast cancer in females.

Efficacy of nutritional intervention in breast cancer patients: a randomized clinical case control trial