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Silver nanoparticles (AgNPs) have gained interest as an alternative pharmaceutical agent because of antimicrobial resistance and drug toxicity. Considering the increasing request, eco-friendly, sustainable, and cost-effective synthesis of versatile AgNPs has become necessary. In this study, green-made AgNPs were successfully synthesized using  Micromonospora  sp. SH121 (Mm-AgNPs). Synthesis was verified by surface plasmon resonance (SPR) peak at 402 nm wavelength in the UV-Visible (UV-Vis) absorption spectrum. Scanning electron microscopy (SEM) analysis depicted that Mm-AgNPs were in the size range of 10–30 nm and spherical. Fourier transform infrared spectroscopy (FTIR) confirmed the existence of bioactive molecules on the surface of nanoparticles. The X-ray diffraction (XRD) analysis revealed the face-centered cubic (fcc) structure of the Mm-AgNPs. Their polydispersity index (PDI) and zeta potential were 0. 284 and −35.3 mV, respectively. Mm-AgNPs (4–32 µg/mL) exhibited strong antimicrobial activity against  Bacillus cereus ,  Enterococcus faecalis ,  Enterococcus hirae ,  Escherichia coli ,  Klebsiella pneumoniae ,  Proteus vulgaris ,  Pseudomonas putida ,  Staphylococcus epidermidis ,  Streptococcus pneumoniae , and  Aspergillus flavus . Mm-AgNPs partially inhibited the biofilm formation in  Acinetobacter baumannii ,  E. coli ,  K. pneumoniae , and  Pseudomonas aeruginosa . Furthermore, results showed that low concentrations of Mm-AgNPs (1 and 10 µg/mL) caused higher cytotoxicity and apoptosis in DU 145 cells than human fibroblast cells. Based on the results, Mm-AgNPs have an excellent potential for treating infectious diseases and prostate cancer.

Antimicrobial, antibiofilm, and anticancer potential of silver nanoparticles synthesized using pigment-producing Micromonospora sp. SH121